"Regulation of immature cartilage growth by IGF-I, TGF- β 1, BMP-7, an" by Anna Asanbaeva, Koichi Masuda et al. * Home * Search * Browse Collections * My Account * About * Digital Commons Network™ Skip to main content * Home * FAQ * About * My Account * < Previous * Next > * * Home > * Research > * Faculty Research > * College of Engineering > * Mechanical Engineering > * 15 Mechanical Engineering Regulation of immature cartilage growth by IGF-I, TGF- β 1, BMP-7, and PDGF-AB: role of metabolic balance between fixed charge and collagen network Author Info * Anna Asanbaeva , University of California - San Diego * Koichi Masuda , Rush University * Eugene J-M.A. Thonar , Rush University * Stephen M. Klisch , California Polytechnic State University - San Luis Obispo Follow * Robert L. Sah , University of California - San Diego Recommended Citation Published in Biomechanics and Modeling in Mechanobiology , Volume 7, Issue 4, August 1, 2008, pages 263-276. Abstract of paper. The definitive version is available at https://doi.org/10.1007/s10237-007-0096-8 . Abstract Cartilage growth may involve alterations in the balance between the swelling tendency of proteoglycans and the restraining function of the collagen network. Growth factors, including IGF-I, TGF-β1, BMP-7, and PDGF-AB, regulate chondrocyte metabolism and, consequently, may regulate cartilage growth. Immature bovine articular cartilage explants from the superficial and middle zones were incubated for 13 days in basal medium or medium supplemented with serum, IGF-I, TGF-β1, BMP-7, or PDGF-AB. Variations in tissue size, accumulation of proteoglycan and collagen, and tensile properties were assessed. The inclusion of serum, IGF-I, or BMP-7 resulted in expansive tissue growth, stimulation of proteoglycan deposition but not of collagen, and a diminution of tensile integrity. The regulation of cartilage metabolism by TGF-β1 resulted in tissue homeostasis, with maintenance of size, composition, and function. Incubation in basal medium or with PDGF-AB resulted in small volumetric and compositional changes, but a marked decrease in tensile integrity. These results demonstrate that the phenotype of cartilage growth, and the associated balance between proteoglycan content and integrity of the collagen network, is regulated differentially by certain growth factors. Disciplines Mechanical Engineering Download DOWNLOADS Since March 11, 2009 Included in Mechanical Engineering Commons Share COinS URL: https://digitalcommons.calpoly.edu/meng_fac/15 Search Enter search terms: Select context to search: in this series in this repository across all repositories Advanced Search * Notify me via email or RSS Browse * Disciplines * Collections * Authors Author Corner * Submit LINKS * Cal Poly, San Luis Obispo * Robert E. Kennedy Library * Mechanical Engineering Department Elsevier - Digital Commons Undergraduate Research Commons | Cal Poly Website Accessibility Statement | bepress Accessibility Statement Privacy Copyright